Cancer

Advances in Cancer Research, Vol. 108 - download pdf or read online

By George F. Vande Woude (ed.), George Klein (ed.)

ISBN-10: 012380888X

ISBN-13: 9780123808882

Offers worthwhile info at the interesting and fast-moving box of melanoma research. Outstanding and unique reports are awarded on numerous issues.

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Extra resources for Advances in Cancer Research, Vol. 108

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2007). These data thus suggested that certain genotype B strains may be associated with the development of HCC in young HBV carriers. However, the pathogenesis remains to be investigated. , 2004). , 2007b). HBV genotypes also influence the clinicopathologic features of patients with resectable HCC. Among 193 patients with resectable HBV-related HCC in Taiwan, genotype B patients were less associated with cirrhosis compared with genotype C patients (33% vs. 01). Pathologically, genotype B patients had a higher rate of solitary tumor (94% vs.

Viral Load The impact of baseline viral load at enrollment on the risk of cirrhosis and HCC development over time has been increasingly recognized in HBV carriers aged between 30 and 65 years. In a population-based prospective cohort including seven townships in Taiwan, 3582 untreated HBV carriers were enrolled (REVEAL-HBV study; Fig. 3). , 2006). According to this landmark study, the higher the serum HBV DNA level at early 1990s, the higher the risk of cirrhosis and HCC development at early 2000s (Fig.

2009a). These data suggest that virologic differences may exist among HBV genotypes; however, whether immunopathogenesis differs between various HBV genotypes need further studies. , 2007a). This observation may correlate with different outcomes of immunomodulatory treatment and the progression of liver disease in HBV carriers infected with different genotypes. In summary, virologic differences and subsequent interactions with host immune responses may influence clinical outcomes and epidemiologic characteristics of patients with different HBV genotype infections.

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Advances in Cancer Research, Vol. 108 by George F. Vande Woude (ed.), George Klein (ed.)


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